This is an alert to regular migraine sufferer who’s already familiar with Topiramate or Topamax and usually used it as their prescription when dealing with migraine; recent research has revealed that using Topiramate constantly can boost your chance and increase the risk of forming kidney stones.
More than 29 million Americans were suffered by migraine these days, according to study by Dr. Dion Graybeal, assistant professor of neurology. Base on release from the National Headache Foundation, Topiramate is one of the most commonly prescribed and effective medications for migraines.
Senior author and chief of mineral metabolism at the University of Texas South Western Medical Center at Dallas, Dr. Khashayar Sakhaee publish a statement that the widespread and escalating use of Topiramate emphasizes the importance of considering the long-term impact of this drug on kidney stones formation.
The research involving two part of group, one group are consist of 32 people whose had been in topiramate drug treatment and the other group are consist of 7 people with kidney stone risk was assessed before, three months after they took topiramate. There is 50 people in total who involved in this research are taking a blood and urine test to determine their risk in developing kidney stones.
The result is quite surprising, the research found that the group who dealing with topiramate treatment on a long-term basis, approx. about a year have experienced a systemic metabolic acidosis or a condition of increasing excessive acid in the blood, as a result of the less function of the kidney to excrete acid.
This research also finds out the fact that long-term treatment using Topiramate would increased urine pH and lowered urine citrate, which is would trigger kidney stones formation. These changes also increase the risk of calcium phosphate kidney stone or well known, as calcium stones. But luckily this research found no evidence that short-term Topiramate treatment will causes same condition as long-term user, in other word, using Topiramate in short term will not increase the risk of kidney stones.
Compile and re-written based on article by Health Day News
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